Title

Experimental Reduction of MiR-92a Mimics Arterial Aging

Document Type

Article

Publication Date

2016

Keywords

Age related arterial dysfunction, endothelial dependent dilation, microRNA

Abstract

MicroRNAs (miRs) are small non-coding RNAs that are important regulators of aging and cardiovascular diseases. MiR-92a is important in developmental vascular growth and tumorigenesis and two of its putative targets, tumor necrosis factor alpha receptor 1 (TNFR1) and collagen type 1, play a role in age-related arterial dysfunction. We hypothesized that reduced miR-92a expression contributes to age-related arterial dysfunction characterized by endothelial dysfunction and increased large artery stiffness. MiR-92a is reduced 39% (RT-PCR, p

Published In

Experimental Gerontology

Volume

83

Pages

165-170

DOI

10.1016/j.exger.2016.08.007