Experimental Reduction of MiR-92a Mimics Arterial Aging
Age related arterial dysfunction, endothelial dependent dilation, microRNA
MicroRNAs (miRs) are small non-coding RNAs that are important regulators of aging and cardiovascular diseases. MiR-92a is important in developmental vascular growth and tumorigenesis and two of its putative targets, tumor necrosis factor alpha receptor 1 (TNFR1) and collagen type 1, play a role in age-related arterial dysfunction. We hypothesized that reduced miR-92a expression contributes to age-related arterial dysfunction characterized by endothelial dysfunction and increased large artery stiffness. MiR-92a is reduced 39% (RT-PCR, p
Hazra S, Henson GD, Morgan RG, Breevoort SR, Ives SJ, Richardson RS, Donato AJ, Lesniewski LA. Experimental reduction of miR-92a mimics arterial aging. Exp Gerontol. 2016 Oct;83:165-70. doi: 10.1016/j.exger.2016.08.007. Epub 2016 Aug 11. PubMed PMID: 27523918; PubMed Central PMCID: PMC5013538.